The experiment investigated the role of green tea treatment of UVB skin photocarcinogenesis with or without the co-carcinogen arsenite. 260 mice were divided into six groups each of 36. Group (1) was control. Group (2) received sodium arsenite in water. Group (3) was UVB radiated. Group (4) was arsenite treated and UVB radiated. Group (5) was UVB radiated and treated with green tea. Group (6) was radiated with arsenite and green tea treated.
Green tea treatment of ultraviolet-B ( UVB ) skin carcinogenesis in mice
Abstract:
The experiment investigated the role of green tea treatment of UVB skin photocarcinogenesis with or without the co-carcinogen arsenite. 260 mice were divided into six groups each of 36. Group (1) was control. Group (2) received sodium arsenite in water. Group (3) was UVB radiated. Group (4) was arsenite treated and UVB radiated. Group (5) was UVB radiated and treated with green tea. Group (6) was radiated with arsenite and green tea treated.
Specimens from skin, lymph nodes, lung, liver, kidneys, and spleen were taken at 9 months from group (I) & (2) and monthly after four months exposure in the other groups. Paraffin sections were stained by H&E. UVB radiation induced: dysplastic changes in epidermis, preneoplastic hyperplasia of rete pegs, hyperplasia of hair follicles, trichofolliculoma, trichofolliculocarcinoma, squamous cell carcinoma, basal cell carcinoma and fibropapilloma.
Green tea treatment prevented the induction of rete pegs preneoplastic hyperplasia, hair follicle hyperplasia, trichofolliculocarcinoma, squamous cell carcinoma, fibropapilloma, rhabdomyosarcoma and mixed tumors.
Green tea reduced the incidence and delayed the appearance of dysplastic changes and trichofolliculoma. Arsenite has no co-carcinogenic effect. Green tea has no significant effect in the arsenite UVB group
size : 2 mg
Green tea treatment of ultraviolet-B ( UVB ) skin carcinogenesis in mice
